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KMID : 0613820090190030299
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Journal of Life Science
2009 Volume.19 No. 3 p.299 ~ p.304
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Human IL-27p28 Gene Polymorphisms are Associated with the Serum Total IgE Levels of Allergic Rhinitis Patients
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Yu Ji-In
Kim Hun-Soo
Moon Hyung-Bae
Han Won-Cheol
Lee Jae-Hoon
Lee Jae-Hun
Yun Ki-Jung
Chae Soo-Cheon
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Abstract
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Interleukin 27 (IL-27) was discovered as a heterodimeric cytokine of the IL-12 family, and is composed of two subunits - Epstein-Barr virus induced gene 3 (EBI3) and p28. It acts as a versatile cytokine in the early regulation of Th1 initiation and in the negative regulation of the Th2 factor GATA binding protein 3 (GATA-3). This cytokine is mediated by the IL-27 receptor (WSX-1), which is highly expressed on CD4? T lymphocytes and NK cells. We previously identified four polymorphisms in the human IL-27p28 gene and suggested that the polymorphism of IL-27p28 is associated with susceptibility to asthma. To determine whether these IL-27p28 SNPs are associated with susceptibility to allergic rhinitis, the genotype and allele frequencies of IL-27p28 SNPs were analyzed between allergic rhinitis patients and healthy controls. Although the genotype and allele frequencies of IL-27p28 SNPs in allergic rhinitis patients were not significantly different from those of the control group, there was a suggestive difference (P=0.037) between these groups in total serum IgE levels in the g.2905T＞G SNP of the IL-27p28 gene. Our result implies that the g.2905T＞G SNP of the IL-27p28 gene might have an affect on IgE production in allergic rhinitis patients.
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KEYWORD
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Interleukin 27 (IL-27), polymorphism, haplotype, allergic rhinitis, IgE
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